An innovative approach to neurodegenerative diseases
Research on neurodegenerative diseases, such as Parkinson’s disease and Huntington’s chorea, is making great strides thanks to an ambitious project led by Elena Cattaneo, a professor at the University of Milan. With a grant of 10 million euros from the European Research Council (ERC), Cattaneo and an international team of researchers are preparing to develop personalized cell therapies to address these devastating disorders.
The project and its objectives
The project, entitled Custom-made Neurons for Cell Therapy in Parkinson’s and Huntington’s disease, will last six years and will involve prestigious institutions, including the University of Turin and the Technical University of Denmark. The researchers aim to:
- Using embryonic stem cells to develop specific treatments.
- Create self-regulating cells that can adapt to individual patient needs.
- Develop brain organoids to study damaged neural circuits.
Cattaneo stressed that Parkinson’s disease can manifest itself in different ways, thus requiring tailored therapies. Research will focus not only on the degeneration of dopamine neurons but also on the associated cognitive dysfunctions.
Cattaneo said that current Italian regulations limit the derivation of embryonic stem cells, but allow acquisition from foreign institutions. This situation highlights a contradiction in the regulatory system, considering that the ultimate goal is to bring hope to patients.
Towards a promising future
The future of neurodegenerative disease research looks bright thanks to the efforts of the scientists involved in the project. With the help of embryonic stem cells and innovative 3D modeling of brain circuits, scientists are getting closer to better understanding the mechanics of neurodegenerative diseases.
The outlook is optimistic: the possibility of personalized cell therapies could revolutionize the treatment of Parkinson’s disease and Huntington’s chorea, offering new hope to millions of patients worldwide. Research continues to advance, bringing with it the promise of a future in which neurodegenerative diseases can be addressed with greater effectiveness and humanity.